Topics : Takeda Pharmaceutical Co Ltd could start a clinical trial as early as July for a potential treatment of COVID-19 that is based on antibodies from recovered patients’ blood, company executives said on Wednesday.The clinical trial would include hundreds of patients and take several months to complete. If successful, Japan’s Takeda could file for approval by US authorities this year, said Julie Kim, president of the plasma-derived therapies unit of Takeda.”When the product will be available beyond the clinical study is still a bit unclear,” Kim said on an investor call. “But we do expect that before the end of the year, we should see some information in terms of broader use.” “It is a scarce resource,” Kim said. “Antibodies don’t last forever and we have to capture people within that time window. This is dependent on the progression of COVID-19 within different geographies.”Takeda said last week it has joined with nine other companies that work on blood plasma-based therapies to develop a treatment for COVID-19 patients. The CoVIg-19 Plasma Alliance also includes Biotest AG, CSL Behring, and Octapharma Plasma, among others.Takeda is working with the US National Institute of Health (NIH) on a clinical trial that would give all the companies in its partnership the ability to produce the treatment, which will not have standard drug industry patent protections because it uses existing technology. Fighting disease with blood from survivors is an ancient strategy that has not been well tested for the novel coronavirus, which emerged in China late last year and has spread around the world. Some hospitals are already collecting blood plasma from recovered patients and infusing it into people who are sick with the coronavirus, but its efficacy is still being studied.The new coronavirus has infected 4.3 million people worldwide and nearly 300,000 have died, according to a Reuters tally. The pandemic has spurred several drugmakers to race to develop a viable treatment or vaccine.Takeda’s proposed treatment offers a standardized dose of antibodies. It also has a much longer shelf life than unprocessed blood plasma and doesn’t need to be limited to patients with matching blood types. There are not yet any treatments for COVID-19, the disease caused by the coronavirus, which have been approved by the US Food and Drug Administration. However, some such as Gilead Sciences Inc’s antiviral drug remdesivir have received emergency authorization from the regulator.The number of patients who could be aided by Takeda’s treatment, initially called TAK-888, depends in part on the availability of blood donations, Kim said in an interview with Reuters.
Will Ozzie Guillen or Dusty Baker get another chance to manage a baseball team? Guillen was last with Miami, and Baker was with the Reds. In the case of Guillen, he almost had the Miami job back this spring. However, because of some complications with his old contract, they decided to go to one of their front office people. As far as Baker is concerned, he has not been on the field since the Reds let him go.Ozzie is again being considered for the Miami job mainly because of his familiarity with the south Florida fan’s language. As far as Baker is concerned, he has been mentioned as a prime candidate to fill the Dodgers’ vacancy. After all, Dusty is a Californian and played with the Dodgers.Both of these former managers were well liked by their players. Guillen got in trouble with management because of his mouth. Baker had trouble with management because they said he was not tough enough on his players. In both cases, the teams that fired them have been a disaster ever since.
Source: BBC Neymar will miss the 2019 Copa America on home soil after rupturing a ligament in his ankle during Brazil’s 2-0 friendly win over Qatar in Brasilia.The Paris St-Germain forward, 27, who was stripped of the Brazilian captaincy in May, limped off after 17 minutes.Everton’s Richarlison had put the hosts ahead after 16 minutes and Manchester City striker Gabriel Jesus added a second eight minutes later.The 12-team Copa America tournament starts on Friday, 14 June.Neymar was taken to hospital for a scan after being helped off the pitch by members of the Brazil support staff, having appeared to twist his ankle.Brazil coach Tite, who on Monday described the forward as “indispensable” but not “irreplaceable” in the team, initially believed the injury would not be “very serious”.Neymar, who joined PSG from Barcelona for a world record 222m euros in August 2017, missed three months between January and April earlier this year after breaking a metatarsal in his right foot.He also missed three months following surgery on the same injury in 2018, returning just in time to play in the World Cup.The hosts are attempting to win South America’s continental tournament for the first time since 2007.