Women may mount stronger COVID-19 immune response

first_imgTreated differently? But the study has limitations.Firstly, the sample size was relatively small, with 98 patients in total. The average age of the patients was also high, at around sixty years.Commenting on the research, Eleanor Riley, a professor at the University of Edinburgh, said some of the divergence noted in the study is “likely due to differences in age or BMI [the sex differences disappear once these other factors are taken into account]”. BMI measures body fat.She said others could have arisen “by chance”.”Importantly, although the average response may differ between men and women, the range of most of the measurements in men and women overlap significantly, meaning that many women have responses that are indistinguishable from those of many men,” she added. Riley said this is why treatments would be better if they were individually tailored, rather than defined solely on sex.  Topics : Researchers found that women mounted a more robust immune response involving T lymphocytes, which are a type of white blood cell that can recognize viruses and eliminate them.  This was the case even among older women, the study found. In contrast, older men had weaker T cell activity — the older they were, the weaker the response. Overall men also produced more cytokines, which are inflammatory proteins that form another part of the body’s natural immune defense. However, severe cases of COVID-19 have been linked to what is known as a “cytokine storm”, when the immune system goes into overdrive, which is harmful and potentially deadly. Men who showed high concentrations early on were more likely to have a severe case of the disease, while those women who also showed significant cytokine levels also appeared to fare worse, the study found. According to the authors, this could imply that men and women need different treatments.For men, for example “we should be enhancing their T cell responses with vaccines” Iwasaki said, while women could be given treatment to dampen the cytokine response.   A new study looking at male and female immune responses to the new coronavirus may shed new light on why men are more likely to become seriously ill with COVID-19, researchers said Wednesday.     Since early in the pandemic it has been clear that men, particularly older men, are at a far higher risk of dying from the virus than women of a similar age, but scientists have not yet been able to pinpoint exactly why. A new study published in the journal Nature noted that globally men account for about 60 percent of deaths from COVID-19 and looked at whether differences in immune responses could explain why. “What we found was that men and women indeed develop different types of immune responses to COVID-19,” said the study’s lead author Akiko Iwasaki, a professor at Yale University, in a video. The immunity specialist said “these differences may underlie heightened disease susceptibility in men”. Researchers collected nasal, saliva, and blood samples from non-infected control subjects and patients with the disease who were treated at Yale New Haven Hospital in the United States.  They then monitored patients to look at their immune responses.last_img read more

Chelsea warned against replacing under-fire manager Maurizio Sarri with Frank Lampard

first_imgChelsea legend Frank Lampard is currently in charge of Derby County (Picture: Getty)Chelsea have been warned against replacing under-fire manager Maurizio Sarri with club legend Frank Lampard.Italian boss Sarri only arrived at Stamford Bridge last summer but is already clinging on to his job at Chelsea.Having lost three of their last four Premier League fixtures, Chelsea have slipped to sixth in the Premier League and were thrashed 6-0 by Manchester City last weekend.Sarri’s struggles have led to speculation over his future in west London and Chelsea legend Lampard has been touted as a potential successor.ADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityBut Arsenal hero Paul Merson says it is too early to view Lampard – the current Derby County manager – as a candidate to take over at Chelsea.AdvertisementAdvertisementAsked whether Lampard could manage his former club, Merson told Sky Sports: ‘Not yet. It’s a big job.‘They’re not Norwich, they’re not 10 points clear at the top. It’s early.‘I think he’s doing great, don’t get me wrong. But there’s a long way to go. Metro Sport ReporterSunday 17 Feb 2019 12:26 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link1.2kShares Advertisement Blues boss Maurizio Sarri (Picture: Getty) Chelsea v Man Utd: Gianfranco Zola previews FA Cup tieTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 12:08FullscreenChelsea v Man Utd: Gianfranco Zola previews FA Cup tiehttps://metro.co.uk/video/chelsea-v-man-utd-gianfranco-zola-previews-fa-cup-tie-1864186/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.‘You’re talking one of the top four, five clubs in England. One of the top 20 in the world of football. It’s a bit early for me.’Lampard’s Derby County are currently seventh in the Championship, outside the play-off places only on goal difference.Speaking last week, the former England midfielder downplayed speculation linking him with the manager’s job at Stamford Bridge.‘It is certainly a club I respect and a manager that I respect so it wouldn’t make me smile or anything different because my job is here,’ he said.‘I obviously follow Chelsea, have huge respect for them, and I hope to see them, put some form together and turn those results around.’More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves Chelsea warned against replacing under-fire manager Maurizio Sarri with Frank Lampard Comment Advertisementlast_img read more

Queensland renovation boom as spending hits just under $1.5 billion

first_imgAFTER: Morningside residence designed by Kieron Gait Architects took out the 2018 Houses Award for House Alteration & Addition over 200 sqm. Picture: Christopher Frederick Jones.“At a time when Brisbane is losing significant numbers of its historic housing stock to demolition or unsympathetic makeovers, the Morningside Residence provides an enduring alternative that is more true to culture and place,” the judges’ citation said.Zuzana Kovar, who along with partner Nicholas Skepper, saw their firm become Australia’s best emerging architecture practice, said it was not hard to believe that Queensland had reached almost $1.5b in renovation spending annually. BEFORE: The space underneath the cottage was virtually dead space before renovation. Architects Zuzana Kovar and Nicholas Skepper at their home business where 95 per cent of their work was renovations now. Picture: Mark Cranitch.The most popular renovations Queenslanders wanted, she said, were adding space, opening up homes for indoor-outdoor living or reworking internal space to suit growing families. “People want more space than when these houses were built 100 years ago.” sophie.foster@news.com.au Follow Sophie Foster on Facebook AFTER: Terrarium house by architecture firm John Ellway reimagined the undercroft in an award-winning fashion. Picture: Toby ScottJudges commended John Ellway for exploiting the natural fall in the site to insert living spaces into the once unused undercroft of the home.“The compactness of the house is its triumph; circulation flows seamlessly from one space to another and not one inch is wasted, with notable Japanese influences.”Morningside Residence by Kieron Gait Architects in Brisbane’s inner-city suburb of Morningside was Australia’s best house alteration and addition over 200 sqm, with the judges calling the renovation “a quiet, respectful and poetic addition to a 1920s Queenslander”. Monash Road House in Tarragindi by Zuzana and Nicholas was highly commended by judges in the House Alteration & Addition under 200 sqm category. Picture: Toby Scott.”In inner-city areas where you don’t have the option to demolish the house, you have to keep it and work with it, then the only option is to invest in renovation or extension. A lot of people are interested in retaining the character as well. It becomes sentimental to them.”Ms Kovar expected spending on upgrades to continue to rise — pushed along by older building stock hitting a century and strict limits on demolition in character areas. BEFORE: The worker’s cottage before John Ellway redesigned it into Australia’s best renovation under 200sq m. Picture: realestate.com.au BEFORE: The veranda area came straight off the pavement on the right before John Ellway’s redesign. AFTER: The veranda area was converted into an open air green space with stairs leading down into the undercroft living space. Picture: Toby ScottAustralia’s best house alteration and addition under 200sq m was a worker’s cottage, Terrarium House in Highgate Hill designed by John Ellway, which was transformed “into a luscious, planted oasis”.More from newsParks and wildlife the new lust-haves post coronavirus17 hours agoNoosa’s best beachfront penthouse is about to hit the market17 hours ago AFTER: The back of the cottage now: Terrarium House in Highgate Hill, architect John Ellway. Picture: Toby ScottThis as Queenslanders celebrated scooping national renovation gongs on Friday at the 2018 Houses Awards — with a worker’s cottage and a Queenslander emerging as the top renovated properties in Australia.Add to that a small Brisbane firm, Red Hill-based Zuzana and Nicholas, was named the country’s best emerging architecture practice, with 95 per cent of their work now focused on renovations and one of their renovation projects Monash Road House in Tarragindi highly commended by judges. Architects Zuzana Kovar and Nicholas Skepper ’s home-based business, Zuzana and Nicholas, has been named Australia’s best emerging architecture practice. Picture: Mark Cranitch.QUEENSLANDERS are officially the best renovators in the country, scooping top national awards as latest data showed spending on upgrades has hit record levels here.Just shy of $1.5 billion ($1.435b) was spent tweaking Queensland homes via alterations, additions and conversions in latest annual figures released by the Australian Bureau of Statistics.The renovation spend was a rise of just over $13.4 million in the four quarters to March compared to the same period the previous year. ABS figures released this month said. AFTER: Morningside Residence designed by Kieron Gait Architects was praised for its “respectful” redesign. Picture: Christopher Frederick JonesShe said there were some homeowners in Brisbane spending half a million dollars on renovation work, with much of the spending involving building underneath a home, sometimes on sloping sites, with significant excavation, restumping and structural work.”Average spend varies depending on how much they want to add and depending on the state of the existing house. Sometimes they could be not adding much but the house is in such a bad state it goes to that. Sometimes it’s minor things and repainting then most of the budget is given to adding new spaces. It can vary from $100-150,000 all the way up to $500,000,” she told The Courier-Mail. BEFORE: This is how the back of the Morningside property looked before it underwent renovations. BEFORE: The Morningside property was solid but needed updating for modern family life.last_img read more